The Mega Man ZX series made its debut in 2006 on the Nintendo DS and is set over 200 years after the events of the Mega Man Zero series.
In this new era, the difference between humans and Reploids has become nonexistent, and a new combination of “man and machine,” called “Humanoids” has emerged. A new series of “Maverick” uprisings begins to occur, which proves to be a dangerous threat since all beings on Earth are now part machine in nature and thus susceptible to the outbreak. Vent/Aile, orphans from a Maverick outbreak that occurred ten years ago, get drawn into the new conflict, along with Girouette, the head of their delivery team